@article{He2014759,
title = {Synergistic combination of marine oligosaccharides and azithromycin against Pseudomonas aeruginosa},
author = { X.a b He and H.-M.b Hwang and W.G.b Aker and P.a Wang and Y.c Lin and X.a Jiang and X.d He},
url = {http://www.scopus.com/inward/record.url?eid=2-s2.0-84904730527&partnerID=40&md5=7a9b2ae75de712bea703d565dd34f1f3},
doi = {10.1016/j.micres.2014.01.001},
issn = {09445013},
year = {2014},
date = {2014-01-01},
journal = {Microbiological Research},
volume = {169},
number = {9-10},
pages = {759-767},
publisher = {Urban und Fischer Verlag Jena},
abstract = {In this paper we describe how utilization of low molecular weight alginate-derived oligosaccharide (ADO) and chito-oligosaccharide (COS) in conjunction with antibiotics, could more effectively inhibit the growth of wild-type and resistant Pseudomonas aeruginosa. Inhibition is effected by modulating the bacteria's quorum sensing (QS) system, thus regulating biofilm formation and reducing resistance to antibiotic treatment. This can be demonstrated by using conventional MIC screening. COS showed synergistic effects with azithromycin, whereas ADO indicated additive effects against wild-type P. aeruginosa. Using electrospray-ionization mass spectroscopy (ESI-MS), matrix-assisted laser desorption/ionization-time of flightmass spectroscopy (MALDI-TOF-MS) and nuclear magnetic resonance (NMR), the chemical structure of ADO and of COS was characterized. The wild-type and resistant strains were identified by 16S rRNA sequence analysis. This report demonstrates the feasibility of attenuating the tolerance of P. aeruginosa to azithromycin by using specific marine oligosaccharides. © 2014 Elsevier GmbH.},
note = {cited By 1},
keywords = {16S; Sequence Analysis, Alginate, Anti-Bacterial Agents; Azithromycin; Biofilms; DNA, Antibiotics; Bacteria; Electrospray ionization; Mass spectrometry; Nuclear magnetic resonance spectroscopy; Oligosaccharides; RNA, antiinfective agent; azithromycin; bacterial DNA; oligosaccharide; ribosome DNA; RNA 16S, Bacteria (microorganisms); Pseudomonas aeruginosa, Bacterial; DNA, biofilm; chemical structure; chemistry; classification; DNA sequence; drug effects; drug potentiation; electrospray mass spectrometry; genetics; growth, Chito-oligosaccharides; Low molecular weight; Matrix assisted laser desorption; Nuclear magnetic resonance(NMR); Pseudomonas aeruginosa; Quorum-sensing; Resistance to antibiotics; Synergistic combinations, development and aging; mass spectrometry; microbial sensitivity test; molecular genetics; nuclear magnetic resonance spectroscopy; physiological stress; physiology; Pseudomonas aeruginosa; quorum sensing, DNA; Spectrometry, Electrospray Ionization; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Stress, Physiological, Ribosomal, Ribosomal; Drug Synergism; Magnetic Resonance Spectroscopy; Microbial Sensitivity Tests; Molecular Sequence Data; Molecular Structure; Oligosaccharides; Pseudomonas aeruginosa; Quorum Sensing; RNA},
pubstate = {published},
tppubtype = {article}
}

@article{He2014759b,
title = {Synergistic combination of marine oligosaccharides and azithromycin against Pseudomonas aeruginosa},
author = { Hwang H.-M. Aker W G Wang P Lin Y Jiang X He X He X.},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84904730527&partnerID=40&md5=7a9b2ae75de712bea703d565dd34f1f3},
doi = {10.1016/j.micres.2014.01.001},
year = {2014},
date = {2014-01-01},
journal = {Microbiological Research},
volume = {169},
number = {9-10},
pages = {759--767},
abstract = {In this paper we describe how utilization of low molecular weight alginate-derived oligosaccharide (ADO) and chito-oligosaccharide (COS) in conjunction with antibiotics, could more effectively inhibit the growth of wild-type and resistant Pseudomonas aeruginosa. Inhibition is effected by modulating the bacteria's quorum sensing (QS) system, thus regulating biofilm formation and reducing resistance to antibiotic treatment. This can be demonstrated by using conventional MIC screening. COS showed synergistic effects with azithromycin, whereas ADO indicated additive effects against wild-type P. aeruginosa. Using electrospray-ionization mass spectroscopy (ESI-MS), matrix-assisted laser desorption/ionization-time of flightmass spectroscopy (MALDI-TOF-MS) and nuclear magnetic resonance (NMR), the chemical structure of ADO and of COS was characterized. The wild-type and resistant strains were identified by 16S rRNA sequence analysis. This report demonstrates the feasibility of attenuating the tolerance of P. aeruginosa to azithromycin by using specific marine oligosaccharides. textcopyright 2014 Elsevier GmbH.},
keywords = {16S; Sequence Analysis, Alginate, Anti-Bacterial Agents; Azithromycin; Biofilms; DNA, Antibiotics; Bacteria; Electrospray ionization; Mass spectrometry; Nuclear magnetic resonance spectroscopy; Oligosaccharides; RNA, antiinfective agent; azithromycin; bacterial DNA; oligosaccharide; ribosome DNA; RNA 16S, Bacteria (microorganisms); Pseudomonas aeruginosa, Bacterial; DNA, biofilm; chemical structure; chemistry; classification; DNA sequence; drug effects; drug potentiation; electrospray mass spectrometry; genetics; growth, Chito-oligosaccharides; Low molecular weight; Matrix assisted laser desorption; Nuclear magnetic resonance(NMR); Pseudomonas aeruginosa; Quorum-sensing; Resistance to antibiotics; Synergistic combinations, development and aging; mass spectrometry; microbial sensitivity test; molecular genetics; nuclear magnetic resonance spectroscopy; physiological stress; physiology; Pseudomonas aeruginosa; quorum sensing, DNA; Spectrometry, Electrospray Ionization; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Stress, Physiological, Ribosomal, Ribosomal; Drug Synergism; Magnetic Resonance Spectroscopy; Microbial Sensitivity Tests; Molecular Sequence Data; Molecular Structure; Oligosaccharides; Pseudomonas aeruginosa; Quorum Sensing; RNA},
pubstate = {published},
tppubtype = {article}
}